009P University of Cambridge
Summer Meeting July 2005

 

       
   
3H-cAMP accumulation
CRE-luciferase production
  agonist
Log EC50
%isop

Log KD ICI 118551

n
Log EC50
%isop

Log KD ICI 118551

n
  terbutaline
-5.53±0.06
97.5±0.4
-6.24±0.09
5
-5.68±0.13
110.6±3.0
-6.13±0.05**
4
  salbutamol
-5.76±0.08
88.8±3.0
-6.30±0.03
3
-5.76±0.12
108.2±2.0
-6.13±0.06**
4
  cimaterol
-6.73±0.08
86.2±2.5
-6.33±0.07*
5
-6.71±0.04
106.3±1.8
-6.09±0.06**
5
  BRL 37344
-7.38±0.05
79.2±3.4
-6.13±0.04
3
-7.51±0.03
99.2±1.9
-6.02±0.03**
17
  ICI 215001
-7.06±0.06
60.3±2.9
-6.04±0.08
4
-7.27±0.03
89.2±2.8
-5.99±0.05
4
  CL 316243
-6.03±0.04
75.8±4.5
-6.08±0.08
5
-6.17±0.12
99.8±3.8
-5.96±0.11
4
  noradrenaline
-7.14±0.07
96.9±2.2
-5.83±0.08
5
-7.29±0.04
106.9±2.1
-5.89±0.04
7
  adrenaline
-6.55±0.06
96.5±1.8
-5.99±.0.03
4
-6.67±0.04
109.5±2.1
-5.84±.0.08
6
  isoprenaline
-7.35±0.05
100
-5.87±0.05
4
-7.46±0.05
100
-5.75±0.04
21
  labetolol
-5.32±0.06
9.8±0.5
-5.53±0.08*
6
-4.97±0.09
37.4±2.1
-5.47±0.04**
5
  CGP 12177
-6.57±0.09
61.4±1.5
-4.87±0.07**
5
-6.91±0.04
102.5±1.5
-5.24±0.05**
24
  pindolol
-5.67±0.06
39.3±1.0
-5.29±0.05**
7
-5.69±0.05
90.1±4.0
-5.24±0.06**
8
  SR 59230A -7.21±0.04 12.3±0.8 -5.13±0.14** 6 -6.48±0.08 37.5±5.7 -5.17±0.04** 6
 
Log EC50 values, % maximal response to isoprenaline of a range of agonists and log KD values for ICI 11855 . * = p<0.05; ** = p<0.01 when comparing log KD with that obtained in the presence of isoprenaline (ANOVA)