Hepatoprotective activity of Melia azedarach leaf extract against paracetamol induced hepatic damage in rats

Mohammed Ibrahim, Rasheed Ahmed Shaik, Mohammed Fazil Ahmed
13Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences and Allied Hospitals, Kanchanbagh, Hyderabad, Andhra Pradesh, India, 2Nizam Institute of Pharmacy, Deshmukhi, Pochampally (Mandal), Near Ramoji Film City, Nalgonda, Hyderabad, Andhra Pradesh, India

Our aim was to study the hepatoprotective activity of the methanolic leaf extract of Melia azedarach against paracetamol induced treated male rats. The dried powder of leaf extract of Melia azedarach was extracted successively with methanol and concentrated in vacuum. In this study the hepatoprotective activity of the methanolic leaf extract of Melia azedarach was studied on liver damaged (paracetamol induced) male rats. In this study: Over dosing of paracetamol to rats is reported to decrease the activity of anti-oxidative enzymes (GPx, GST, SOD and CAT) in liver. Simultaneous administration of crude extract (500mg/kg of body weight) and paracetamol (2g/kg of body weight) to rats for 7 days protect the loss of functional integrity. Melia azedarach methanolic leaf extract inhibit the oxidation and maintained the activity of antioxidant enzymes to the normal level. We can conclude from this study, that the methanolic leaf extract of Melia azedarach possesses significant hepatoprotective activity due to its antioxidant property.