Free teaching resource: e-Handbook to accompany Microlabs for Pharmacologists

D Modun1, L Bach-Rojecky2. 1University of Split School of Medicine, Department of Pharmacology, 21000 Split, Croatia, 2University of Zagreb School of Pharmacy and Biochemistry, Department of Pharmacology, 10000 Zagreb, Croatia

Microlabs for Pharmacologists is a free PC-based resource for teaching Pharmacology. It consists of several modules about different topics in Pharmacology, and it includes Tutorials, Simulations, Databases, Videos and Case studies. The author of Microlabs, retired Professor of Pharmacology, Hendrik van Wilgenburg, gave his permission to the authors to produce an e-Handbook to accompany Microlabs.

The e-Handbook is primarily focused on Simulations modules of Microlabs, virtual experiments in Pharmacodynamics (Isolated ileum) and Pharmacokinetics (Kinetic). Regarding teaching Pharmacodynamics (PD), the students are guided to draw Concentration-Response curve(s), LineweaverBurk and Schild plots and to determine different PD parameters, like EC50, Emax and pA2, for different agonists and antagonists, by using the provided raw data.

Regarding teaching Pharmacokinetics (PK), the students are guided to draw Time-Concentration curve(s), and to estimate different PK parameters, like t1/2, Cl, Vd and AUC, for different drugs and clinical cases. For the more advanced students, or young scientists, there is a tutorial how to calculate different PK parameters, by using the provided raw data and non-compartmental analysis approach.

E-Handbook about virtual experiments in Microlabs for Pharmacologists will be soon available as a free PDF to download.