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Utilization of Drugs for Treatment of Thyroid Disfunction in Pregnancy Introduction: Common environmental pollution exposures may affect the function of thyroid gland in humans. During the bombing in Serbia twenty years ago, the significant pollution with polychlorinated biphenyls and with depleted uranium radiation was documented. As this substances are known immunomodulatory agents, the potential effects on thyroid function was studied. Objective: To determine the prevalence of thyroid function disorders through monitoring the amount of drugs for the treatment of thyroid gland disorders in pregnant women as the most vulnerable group in population. The study was conducted in the city of Novi Sad (350 000 inhabitants), Serbia, in the period from 1988 to 2011. Methods: All women giving the birth at Clinic of Gynecology and Obstetrics in Novi Sad during the one month period in 1988, 1999, 2007 and 2011 were included. Data about drugs used for thyroid function disorders during pregnancy were recorded. Results: The total number of women followed during the each investigated period was betweeen 300 and 400. In 1988 and 1999 not a single pregnant woman was recorded with thyroid disfunction. In 2007 four women (0.93% of total) were recorded with thyroid disfunction – three with hypothyroidism one with hiperthyroidism. In 2011, eighteen women (4.23% of total) were diagnosed with thyroid disfunction, with fourtheen cases of hypothyroidism and only one of hyperthyroidism. In most cases hypothyroidism was diagnosed as autoimune Hashimoto thyroiditis. Conclusion : The results of our research indicate the possible influence of environmental pollution in Serbia to the thyroid gland function. More detailed study are needed to confirm the results of pilot study. It is also necessary to conduct the large multicentral trial in order to detect the centers with the highest concentration of this pollution.
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