- Alpha Calcitonin gene-related peptide protects the vasculature in L-NAME-induced hypertension
F. Argunhan1, X. Kodji1, A. A. Aubdool1, M. Nandi2, J. E. Clark3, S. D. Brain1. 1Vascular Biology Group, King's College London, London, United Kingdom, 2Institute of Pharmaceutical Science, King's College London, London, United Kingdom, 3The Rayne Institute, King's College London, London, United Kingdom
- Amg9810- a trpv-1 receptor antagonist, in contrast to trpv-1 ko mice, shows similar antidepressant properties to citalopram in burrowing test
L. Nabi, J. Keeble. Institute of Pharmaceutical Sciences, Kings College London, London, United Kingdom
- Analogue A54: a novel competitive antagonist of Englerin A
H. N. Rubaiy1, T. Seitz2, S. Hahn2, A. Choidas3, P. Habenberger3, B. Klebl3, K. Dinkel3, P. Nussbaumer3, H. Waldmann4, M. Christmann2, D. J. Beech1. 1School of Medicine, LICAMM, University of Leeds, Leeds, United Kingdom, 2Institute of Chemistry and Biochemistry, Freie Universit„t Berlin, Berlin, Germany, 3Lead Discovery Center GmbH, Dortmund, Germany, 4Max-Planck-Institut fr Molekulare Physiologie, Dortmund, Germany
- An analysis of the indacaterol-regulated transcriptome in human airway epithelial cells implicates gene expression changes in the beneficial and adverse effects of β2-adrenoceptor agonists in asthma
D. Yan1, O. Hamed1, T. Joshi1, K. C. Jamieson1, R. Newton2, M. A. Giembycz1. 1Physiology & Pharmacology, University of Calgary, Calgary, Canada, 2Cell Biology & Anatomy, University of Calgary, Calgary, Canada
- An assessment of single versus paired-housing on social cognition in the 3-chamber sociability test in the olfactory bulbectomized (OB) rat model of depression
K. L. McHugh1, P. Calcagno1, M. Clarke1, D. Eyerman2, C. Sanchez2, M. Roche3, D. P. Finn1, J. P. Kelly1. 1Pharmacology and Therapeutics, NUI Galway, Galway, Ireland, 2Alkermes, Inc., Massachusetts, 3Physiology, NUI Galway, Galway, Ireland
- An evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs
M. K. Pugsley1, A. Y. Chiang2, B. D. Guth3, J. M. Doyle4, C. M. Foley5, M. Engwall6, J. E. Koerner7, S. Parish8, R. D. Sarazan9. 1Purdue Pharma, Stamford, CT, 2Eli Lilly and Company, Indianapolis, IN, 3Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany, 4Data Sciences International, St. Paul, MN, 5Abbvie, Abbott Park, IL, 6Amgen, Thousand Oaks, CA, 7US FDA, Silver Spring, MD, 8HESI, Washington, DC, 9Independent, Rhinelander, WI
- Antigen challenge results in specific activation of classical pathways for arachidonic acid oxygenation
J. S„fholm1, M. Adner1, D. Balgoma2, A. Fauland2, C. Gomez2, J. Kolmert1, C. Wheelock2, S. Dahl‚n1. 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 2Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
- Antihypertensive effect of hesperidin and losartan in renovascular hypertensive rats
C. Wunpathe1, P. Maneesai1, U. Kukongviriyapan1, P. Prachaney2, P. Pakdeechote1. 1Physiology, Khon Kaen University, Khon Kaen, Thailand, 2Anatomy, Khon Kaen University, Khon Kaen, Thailand
- Antinociceptive effects of delta-9-tetrahydrocannabinol and cannabidiol alone and in combination in the mouse hypertonic saline foot assay
Y. I. Asiri, T. Fung, B. A. MacLeod, E. Puil. Anesthesiology, Pharmacology, & Therapeutics, University of British Columbia, Vancouver, Canada
- Anti-thrombotic efficacy of cyclic nucleotide modulators in combination with a P2Y12 inhibitor
P. C. Armstrong1, P. Ferreira1, M. V. Chan1, C. Shih2, M. H. Lundberg Slingsby1, T. D. Warner1. 1Blizard Institute, Queen Mary University of London, London, United Kingdom, 2Pharmacology, National Defence Medical Centre, Taipei, Taiwan