- Anti-ulcerative colitis potential of the hydroethanolic extract of the dried fruits of Xylopia aethiopica in rats
Newman Osafo, Oduro Yeboah. Kwame Nkrumah University of Science and Technology
- Development of an Intracellular Quantitative Assay to Measure Compound Binding Kinetics
Charles Lay1, Daniel Thomas2, John Evans3, Kelly Gatfield3, Kristopher McCombe4, Alexander Phillipou3, Laurie Gordon3, Emma Jones3, Kristin Riching5, Mahnoor Mahmood6, Peter Craggs3. 1University of Nottingham, 2Arctoris, 3GlaxoSmithKline, 4Queen's University Belfast, 5Promega, 6Cancer Research UK
- Development of Robust and Predictive Machine Learning QSAR Models for Hepatic Stability
Guilherme Martins Silva1, Holli-Joi Sullivan2, Marielle Kinneer Rath2, Vinicius Medeiros Alves2, Eugene Muratov2, Carlos H. Tomich P. Silva1, Alexander Tropsha2. 1University of São Paulo, 2The University of North Carolina at Chapel Hill
- Evaluation of the neuroprotective mechanisms of 7,8-dihydroxyflavone and generation of sustained release nano/microparticles for improved ocular drug delivery
Flavia Messina1, Andrea Cerquone Perpetuini2, Husvinee Sundaramurthi1, Ailis Moran3, Milton English4, Matthew Brooks4, Anand Swaroop4, Madhuri Dandamudi5, Alison L. Reynolds6, Niall O’Reilly7, Breandán N. Kennedy3. 1UCD - Conway Institute, 2Novartis, 3UCD - Conway Institute, 4National Eye Institute - NIH, 5WIT - PMBRC, 6UCD - School of Veterinary Medicine, 7WIT - PMBRC
- Improving the therapeutic index of navitoclax in the treatment of ovarian cancer
Khaled Alrosan. Keele University
- Inhibition of SPRK1 in vivo in mice reduces nociceptive behaviour in a model of chemotherapeutic peripheral neuropathy.
Lucy F Donaldson1, Matthew Swift1, James Hudson1, Jonathan C Morris2, Hamish Toop2, Beth Coyle1, Nigel Mongan1. 1University of Nottingham, 2University of New South Wales
- Role of G Protein-Coupled Receptor Kinase 5 in Animal Model of Cardiac Hypertrophy
Sara Alhaidar, Asma Aloneazi, Anfal Bin Dayel, Nouf Alrasheed, Tahani Alshammary, Rehab Ali. King Saud University
- Targeting SET-PP2A complex as a new avenue for therapeutic targeting of KMT2A-driven acute leukemia
Maria Teresa Esposito. University of Roehampton
- Therapeutic drugs promote differentiation of AML leukemic blasts into a migratory and chemo-resistant phenotype facilitated by the bone marrow microenvironment.
Yolanda Calle1, Yoana Arroyo-Berdugo1, David Greaves1, Ladan Saeed1, Pemela Shangderpa-Lama1, Maria Teresa Esposito1, Eric So2, Lucy Di-Silvio2. 1University of Roehampton, 2King's College London
- Using automated methods to quantify both efficacy and toxicity of compounds for drug development using the nematode worm Caenorhabditis elegans
David Weinkove, Adelaide Raimundo, Michael Fasseas, Frederique Tholozan, Christopher Saunter. Magnitude Biosciences