- Characterization of the M4 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator, VU0467154, at chemo-genetically modified M4 receptors
P. Valuskova1, S. J. Bradley1, J. P. Conn2, A. B. Tobin1. 1Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, United Kingdom, 2Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville,
- Cyclic AMP inhibits platelet aggregation by low concentrations of collagen but phosphorylation is unaffected
J. Clark1, S. Watson1, S. Hill2, S. P. Watson1. 1Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom, 2School of Life Sciences, University of Nottingham, Nottingham, United Kingdom,
- Development of an ex vivo receptor occupancy assay for the Class C GPCR mGlu5
E. Sergeev, E. Howley, K. Bennett, M. Barnes. Heptares Therapeutics Ltd, Welwyn Garden City, United Kingdom,
- Differential regulation of beta2-adrenoceptor stimulated CREB signalling by G protein-coupled receptor kinases in vascular smooth muscle
J. Willets, L. Jones. Dept of Molecular & Cell Biology, University of Leicester, Leicester, United Kingdom,
- Effect of intracellular loop 1 pepducins on ligand-receptor binding kinetics at the CXCR4 receptor
B. Caspar1,2, L. A. Stoddart1,2, J. Goulding1,2, S. J. Briddon1,2, S. J. Hill1,2. 1Division of Pharmacology, Physiology and Neuroscience, University of Nottingham, Nottingham, United Kingdom, 2Centre of Membrane Proteins and Receptors (COMPARE), Nottingham, United Kingdom,
- Elevation of cAMP through inhibition of phosphodiesterases mediates growth suppression in glioblastoma cells
D. Safitri1, L. Kopanitsa2, H. Potter1, I. Winfield1, F. Svensson2, D. Bailey2, G. Ladds1. 1Pharmacology, University of Cambridge, Cambridge, United Kingdom, 2IOTA Pharmaceuticals Ltd, Cambridge, United Kingdom,
- Enhanced performance of the new HTRF® cAMP kit on Gài/o coupled GPCR
L. Affleck, S. Bdioui, S. Junique, N. Douayry, S. Soldevila, E. Bourrier, T. Roux, E. Trinquet. Cisbio, Cisbio, Codolet, France,
- Exploring rapid desensitization of mu-opioid receptors induced by G protein-biased agonists
S. Groom1, A. Conibear2, A. Disney1, S. Husbands1, Y. Li3, L. Toll4, G. Henderson2, E. Kelly2, C. Bailey1. 1Department of Pharmacy & Pharmacology, University of Bath, Bath, United Kingdom, 2School of Physiology, Pharmacology & Neuroscience, University of Bristol, Bristol, United Kingdom, 3Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL, 4Florida Atlantic University, Boca Raton, FL,
- Extracellular Phosphate as a Non-competitive Antagonist of the Calcium-Sensing Receptor
P. P. Centeno1, H. Mun2, A. D. Conigrave2, D. T. Ward1. 1Division of Diabetes, Endocrinology and Gastroenterology, The University of Manchester, Manchester, United Kingdom, 2School of Life and Environmental Sciences, The University of Sydney, Sydney, Australia,
- Homo- and heterooligomerization of the incretin receptors
S. Al-Sabah1, M. Bnemann2, C. Krasel2. 1Dept. of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Kuwait, Kuwait, 2Institute for Pharmacology and Clinical Pharmacy, Philipps-University Marburg, Marburg, Germany,